May in Colon is the cloudiest month of the year. In May, the weather in Colon is typically warm. Average daily high temperature in May is about 20 degrees above zero. On average, Colon has 11 sunny, 9 partly cloudy, 7 rainy, and 4 cloudy days in May. The rains are usually heavy. May as well as April, August, September, and October is considered the most comfortable time to visit Colon.