January in Cayo Santa Maria is the coldest month of the year. In January, the weather in Cayo Santa Maria is typically warm. Average daily high temperature in January is about 24 degrees above zero. On average, Cayo Santa Maria has 17 sunny, 11 partly cloudy, and 3 rainy days in January. The rains are usually light. January as well as February, March, April, and December is considered the most comfortable time to visit Cayo Santa Maria.