October in Cayo Guillermo is the rainiest month of the year. In October, the weather in Cayo Guillermo is typically hot. Average daily high temperature in October is about 28 degrees above zero. On average, Cayo Guillermo has 16 rainy, 11 sunny, 2 cloudy, and 2 partly cloudy days in October. The rains are usually heavy. October as well as {{month_nom: February}}, and {{month_nom: February}} is considered the most uncomfortable time to visit Cayo Guillermo.